Tweaking is a colloquial term with varied meanings depending on the context in which it is used.
Tweaking (Drug Slang)
In the realm of substance abuse, tweaking refers to the erratic and uncontrollable movements exhibited by individuals under the influence of potent drugs, specifically stimulants like amphetamines, including cocaine, crack, and methamphetamine. Such behavior is often accompanied by sensations of itching, as if insects are crawling beneath the skin—a phenomenon known as formication.
Tweaking (Criminal Slang)
Within the context of street culture and criminal activity, tweaking describes erratic or aggressive behavior, such as initiating conflicts with strangers. This term was popularized in part by references in music, such as in the lyrics of Bobby Shmurda's song, where it denotes reckless and aggressive actions.